Aspochracin is an insecticidal non-proteogenic cyclic tripeptide first isolated from Aspergillus ochraceus by Myokei and co-workers at University of Tokyo in 1969. The same authors elucidated its structure which comprises N-methylalanine, N-methylvaline and an ornithine cyclised through the delta rather than the alpha-amino group. The alpha-amino moiety is acylated with an octa-2,4,6-trienoic acid. Aspochracin is known to be non-toxic to mammalian cell lines and its biological activity and pharmacology are largely unexplored.
- Aspochracin, a new insecticidal metabolite of Aspergillus ochraceus Part I. Isolation, structure and biological activities. Myokei R. et al., Agr. Biol. Chem. 33, 10, 1491.
- Structure of aspochracin, an insecticidal metabolite of Aspergillus ochraceus. Myokei R. et al., Tet. Lett. 1969, 695.
- JBIR-15, a new aspochracin derivative, isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04. Motohashi K. et al., Biosci. Biotechnol. Biochem. 2009, 73, 1898.