Aspochracin

Aspochracin

$163.00 - 0.50 mg

$571.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-A1717
CAS #
22029-09-0
Molecular Formula
C23H36N4O4
Molecular Weight
432.56
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Clear

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Application Notes

Aspochracin is an insecticidal non-proteogenic cyclic tripeptide first isolated from Aspergillus ochraceus by Myokei and co-workers at University of Tokyo in 1969. The same authors elucidated its structure which comprises N-methylalanine, N-methylvaline and an ornithine cyclised through the delta rather than the alpha-amino group. The alpha-amino moiety is acylated with an octa-2,4,6-trienoic acid. Aspochracin is known to be non-toxic to mammalian cell lines and its biological activity and pharmacology are largely unexplored.

References

  • Aspochracin, a new insecticidal metabolite of Aspergillus ochraceus Part I. Isolation, structure and biological activities. Myokei R. et al., Agr. Biol. Chem. 33, 10, 1491.
  • Structure of aspochracin, an insecticidal metabolite of Aspergillus ochraceus. Myokei R. et al., Tet. Lett. 1969, 695.
  • JBIR-15, a new aspochracin derivative, isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04. Motohashi K. et al., Biosci. Biotechnol. Biochem. 2009, 73, 1898.

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