Aquastatin B

Aquastatin B

Aquastatin B

$265.00 - 1 mg

$930.00 - 5 mg

All prices in Australian dollars

Code
BIA-A3188
Synonyms
-
CAS #
160219-85-2
Molecular Formula
C30H42O7
Molecular Weight
514.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol, DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Aquastatin B is the acid hydrolysis product of aquastatin A, produced by Fusarium sp. Aquastatin B strongly inhibits enoyl-ACP reductase (FabI) of Staphylococcus aureus. Aquastatin B is active against Bacillus subtilis with MIC 1.6 µg/mL but inactive against S. aureus and S. cerevisiae. Aquastatin B is inactive against NS-1 and NFF cell lines.

References

  • Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties. Hamano K. et al. J .Antibiot. 1993, 46, 1648.
  • Aquastatin C, a new glycoaromatic derivative from Sporothrix sp. FN611. Kwon Y-J. et al. J. Antibiot. 2011, 64, 213.
  • The aquastatin biosynthetic gene cluster encodes a versatile polyketide synthase capable of synthesising heteromeric depsides with diverse alkyl side chains. Sbaraini N. et al. Chem. Sci. 2024, 15, 18872.

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