Apooxytetracycline, α-

Apooxytetracycline, α-

$128.00 - 1 mg

$448.00 - 5 mg

All prices in Australian dollars

CAS #
18695-01-7
Molecular Formula
C22H22N2O8
Molecular Weight
442.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes

α-Apooxytetracycline is a degradation product of oxytetracycline, formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. α-Apooxytetracycline is an important standard for monitoring oxytetracycline stability.

References

  • Reversed-phase high-performance liquid chromatographic method for the assay of oxytetracycline Barnes W.N. et al., J. Chromatog. 1985, 347, 173.
  • Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS. Lykkeberg A.K. et al., Int. J. Pharm. 2004, 34, 325.
  • Terramycin. VI. The structure of 4- and 6-apoterramycin, acid rearrangement products of terramycin. Hochstein F.A. et al., J. Am. Chem. Soc. 1952, 74, 3707.

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