Amicoumacin B

Amicoumacin B

$189.00 - 0.50 mg

$662.00 - 2.50 mg

All prices in Australian dollars

Synonyms
3-Amino-2,3,6-trideoxy-6-[[1-(3,4-dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]amino]-6-oxohexonic acid
CAS #
82768-33-0
Molecular Formula
C20H28N2O8
Molecular Weight
424.44
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
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Application Notes

Amicoumacin B is an isocoumarin produced by B. subtilis. Amicoumacin B is a quorum-sensing inhibitor against Chromobacterium violaceum. Its analogue, amicoumacin A, has strong anti-inflammatory and antiulcer properties in animal models.

References

  • Amicoumacin antibiotic production and genetic diversity of Bacillus subtilis strains isolated from different habitats. Pinchuk I.V. et al. Res. Microbiol. 2002, 153, 269.
  • Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceum. Shi W-P. et al. Nat. Prod. Res. 2020, ahead of print.
  • Amicoumacin-A, a new antibiotic with strong Anti-inflammatory and antiulcer activity. Itoh J. et al. J. Antibiot. 1981, 34, 611.

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