Tiamulin

Tiamulin

$195.00 - 25 mg

$55.00 - 5 mg

All prices in Australian dollars

Code
BIA-T1321
CAS #
55297-95-5
Molecular Formula
C28H47NO4S
Molecular Weight
493.7
Purity
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO and water at pH <5.

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Application Notes

Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity and an ionisable group for salt formation and greater water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Like pleuromutilin, it inhibits protein synthesis by binding to domain V of 23S rRNA.

References

  • New pleuromutilin derivative with enhanced antimicrobial activity. I. Synthesis. Egger H. & Reinshagen H. J. Antibiot. 1976, 29, 915.
  • Pleuromutilin antibiotics. Hunt E. Drugs Future 2000, 25, 1163.

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