Pimaricin

Pimaricin

$195.00 - 25 mg

$55.00 - 5 mg

All prices in Australian dollars

Code
BIA-P1210
Synonyms
Natamycin, A 5283, Delvolan, Delvocid, Myprozine, Natacyn, Natafucin, Pimafucin, Pimafugin, A5263, CL 12625, E235
CAS #
7681-93-8
Molecular Formula
C33H47NO13
Molecular Weight
665.7
Purity
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Pimaricin is a macrocyclic tetraene originally isolated from Streptomyces natalensis in 1957. Pimaricin exhibits broad spectrum antifungal activity against yeast and filamentous fungi by binding specifically to ergosterol to block fungal growth. Unlike the related polyenes, nystatin and filipin, pimaricin does not change the permeability of the plasma membrane. Pimaricin is used in the food industry for surface treatment of cheeses as a mould inhibitor.

References

  • Pimaricin, a new antifungal antibiotic. Struyk A.P. et al., Antibiot. Annual 1957, 5, 878. 2. Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. te Welscher, Y.M. et al., J. Biol. Chem. 2008, 283, 6393.

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