Methacycline

Methacycline

$145.00 - 5 mg

$510.00 - 25 mg

All prices in Australian dollars

Code
BIA-M1467
Synonyms
6-Methyleneoxytetracycline, Metacycline, Rondomycin
CAS #
914-00-1
Molecular Formula
C22H22N2O8
Molecular Weight
442.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Methacycline is a semi-synthetic tetracycline prepared by dehydration of the 6-hydroxy group of oxytetracycline to yield an exocyclic 6-methylene. Like all tetracyclines, methacycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Methacycline has been extensively cited in the literature with over 400 references.

References

  • 6-Methylenetetracyclines. I A new class of tetracycline antibiotics. Blackwood R.K. et al., J. Am. Chem. Soc. 1961, 83, 2773.
  • 6-Methylenetetracyclines. III. Preparation and Properties. Blackwood R.K. et al., J. Am. Chem. Soc. 1963, 85, 3943.
  • A comparison of the in vitro and in vivo activity of methacycline and other tetracycline compounds. Chang T.W. & Weinstein L. Antibiot. Chemother. 1962, 12, 676.

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