Luzopeptin A
Luzopeptin A
$215.00 - 0.50 mg
$755.00 - 2.50 mg
All prices in Australian dollars
- Code
- BIA-L1139
- Synonyms
- BBM-928A
- CAS #
- 75580-37-9
- Molecular Formula
- C64H78N14O24
- Molecular Weight
- 1427.4
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
Download Data Sheets
Application Notes
Luzopeptin A is a member of the echinomycin (quinomycin A) class of antitumor and antibiotic agents that act by forming a stable DNA complex by bis-intercalation. Luzopeptin A is also a potent inhibitor of HIV-1 reverse transcriptase.
References
- BBM-928, a new antitumor antibiotic complex I. Production, isolation, characterization and antitumor activity. Ohkuma, H. et al., J. Antibiot. 1980, 33, 1087.
- Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS virus. Inouye Y.J. Antibiot. 1987, 40, 100.
- Proton exchange in DNA-luzopeptin and DNA-echinomycin bisintercalation complexes: rates and processes of base-pair opening. Leroy J.L. et al., Biochemistry. 1992, 31, 1407.
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