K252A

K252A

$220.00 - 0.50 mg

$770.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-K1225
Synonyms
SF 2370
CAS #
99570-78-2
Molecular Formula
C27H21N3O5
Molecular Weight
467.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumor activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).

References

  • K-252a, a potent inhibitor of protein kinase C from microbial origin. Kase H. et al., J. Antibiot. 1986, 39, 1059.
  • The structures of the novel protein kinase C inhibitors K-252a, b, c and d. Yasuzawa T. et al., J. Antibiot. 1986, 39, 1072.

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