Chlorothricin

Chlorothricin

$185.00 - 1 mg

$650.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1016
Synonyms
K 818A
CAS #
34707-92-1
Molecular Formula
C50H63ClO16
Molecular Weight
955.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

The tetronic acid, chlorothricin, is an unusual macrocyclic antibiotic from a Streptomyces sp., related to kijanimicin, saccharocarcins, tetrocarcins and versipelostatin. Chlorothricin inhibits cholesterol biosynthesis from mevalonate and inhibits pyruvate carboxylases purified from rat liver, chicken liver and Azotobacter vinelandii.

References

  • New cholesterol biosynthesis inhibitors MC-031 (O-demethylchlorothricin), -032 (O-demethyl hydroxy-chlorothricin), -033 and -034. Kawashima A. et al., J. Antibiot. 1992, 45, 207.
  • Mode of action of the macrolide-type antibiotic, chlorothricin. Effect of the antibiotic on the catalytic activity and some structural parameters of pyruvate carboxylases purified from rat and chicken liver. Schindler P.W. et al., Eur. J. Biochem. 1975, 55, 543.
  • Effect on tumor cells of blocking survival response to glucose deprivation. Park H.R. J. Natl. Cancer. Inst. 2004, 96, 1300.

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